Physical improvements down below as well. National Library of Medicine Good hypothesis! We require a human profile pic upon registration on this forum. Post-finasteride syndrome is a term thats used to describe a range of persistent symptoms that occur in a small percentage of men who use the medication finasteride. In these trials, researchers found that finasteride did cause several of the side effects mentioned above, including decreased libido, erectile dysfunction and ejaculation disorder. An Bras Dermatol. Thanks for reaching out. Replacing testosterone helps recover the DHT receptors and is the only treatment known. According to the Post-Finasteride Syndrome Foundation, these may include: ). This reduction in DHT greatly reduces prostate growth and either slows down, stops or reverses hair loss caused by male pattern baldness. The treatment consists of taking large doses of B6 and Zinc, along with a few antioxidants. Just wanna ask advice from a casual weed smoker as in vaping on weekends what would be a good supplement/nutritional addition to counter any negative effects? Thanks in advance. Minoxidil doesnt block DHT. This is the FDA-approved dynamic duo. This field is for validation purposes and should be left unchanged. Use Catuaba bark extract, mucuna pruriens, Tribulus Terrestris, etc. Common adverse events of treatment consist of sexual disorders and a negative affect balance. Epub 2020 Mar 25. How do you explain that? Ive read about him saying this is pro-fat metabolism and Haidut has an article on how hCG is considered a marker for cancer when it is in fact a promotor of cancer in itself because it trigger cell growth. According to the National Institutes of Health, scientific research is underway to better understand the effects of 5-alpha reductase inhibitor drugs like finasteride. A: None of the studies being sponsored by the PFS Foundation currently are actively recruiting patients. But always do blood tests first to see what is really going on. Separately, Sage Therapeutics has allopregnanolone and allopregnanolone analogue products that are currently in trials for various indications, including major depressive disorder and insomnia. Post-finasteride syndrome is leaving behind a slew of victims in its trail. As a result of this, most medical bodies do not officially recognize post-finasteride syndrome as a medical condition. Keywords: Here are a few things you can do: Finasteride binds to 5-R type 2 with high affinity and dissociates very slowly with a half-life of 31 days. A: According to the Finasteride Drug Summary in Prescriber's Digital Reference: Saw palmetto may inhibit 5 alpha-reductase, preventing the conversion of testosterone to dihydrotestosterone. One key indisputable clinical evidence noted in all reported studies with finasteride and dutasteride was that use of these drugs is associated with development of sexual dysfunction, which may persist in a subset of men, irrespective of age, drug dose or duration of study. Punk?. WebWhen we established the PFS Foundation in 2012, our mission was simple: to facilitate research on the characterization, the underlying biologic mechanisms, and potential treatments of post-finasteride syndrome. For example, during the second, third and fourth years of the trial, 5.1 percent of men who used finasteride 5mg reported experiencing erectile dysfunction. Hi man, Id use pregnenolone and D-phenylalanine to counter the long term sides. Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats. Q3: Why do some finasteride patients develop PFS while others never seem to have any problems with the drug? I have had retraction of penis and man boobs. Acta Derm Venereol. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. Alternatively, you can use other treatments, such as those available in our Non-Prescription Hair Loss Kit, to treat male pattern baldness without taking oral finasteride. Other patients report that they become more stable and learn to better cope with the condition over a period of one to three years, rather than return to full health. Its also important to choose an experienced hair transplant surgeon to make sure you get satisfying, natural-looking results. Im wondering if that Has to do with gut health. One of the PFS Foundations chief goals is to achieve universal awareness and acceptance of PFS as a bona fide and serious medical condition. I find this amazing article. Memory, libido, focus, drive, and sociability have all dramatically improved. Always talk to your doctor about the risks and benefits of any treatment. This action is similar to the action of 5-alpha reductase inhibitors, such as dutasteride and finasteride. Brian fog Although increasing number of men report persistent side effects, the medical community has yet to recognize this syndrome nor are there any specific measures to address this serious and debilitating symptoms. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors. The site is secure. Thanks man, much appreciated. A: At the moment, theres no known test for determining whether any finasteride patient will develop PFS. If I work out too much or my job is extra stressful I become symptomatic. WebThis endocrine crash usually occurrs a few days or weeks after the cessation of treatment with 1 mg finasteride in these patients. really have been feeling like an empty husk like described lately, almost like a part of me was ripped out, but maybe one day i can find it again. Hi, no I dont have insomnia. Q11: Id like to get in touch with other PFS patients in my area, or anywhere in the world, for that matter. Vitamin C for erectile dysfunction: the best vitamin for ED? According to the Post-Finasteride Syndrome Foundation, a 501(c)(3) nonprofit corporation thats dedicated to raising funds for research into post-finasteride syndrome, men with post-finasteride syndrome have reported the following physical symptoms: Sexual dysfunction, including a decreased sex drive or complete loss of libido, Loss of morning wood and spontaneous erections, Peyronie's disease (growth of scar tissue in the penis), Sexual anhedonia, or loss of pleasure from sexual stimulation and/or arousal, Ejaculation disorders, such as reduced ejaculatory volume and force, Gynecomastia, or male breast growth and sensitivity, Chronic fatigue and lack of energy and enthusiasm, Muscle pain, weakness, cramps, stiffness and twitching, Rhabdomyolysis (rapid breakdown of damaged or injured skeletal muscle), Dry, thinning skin and decreased production of sebum (an oily substance that products your skin), Melasma (a skin condition that involves patches of dark, discolored skin), Lipoatrophy (loss of fat tissue in specific areas of the body), Increased body mass index (BMI) and fat deposition, Reduced HDL cholesterol levels, raised triglycerides and fasting glucose, Increased rheumatoid factor (proteins produced by the immune system), Optic neuropathy (damage to the optic nerve inside the eyes), Ocular toxicity (drug-induced damage to the eyes). Any idea why that may be? If I do, could I develop PFS after stopping? For example, our Hair Thickening Shampoo features saw palmetto to target DHT and prevent it from damaging your hair follicles. Additionally, the PFS Foundation has been contacted by at least 30 patients who took saw palmetto only, as a hair-loss treatment, and developed symptoms strikingly similar to those experienced by PFS patients. Unfortunately, a small minority of patients report increasing severity of symptoms over time, especially with respect to some of the psychological side effects. I want to try a solution like HCG low dose: The truth of vitamin B6 on DHT for hair growth. National Library of Medicine It would be something if I could get referred to an endocrinologist and expect some understanding, but my impression is thats not how it goes. It can and does, although they typically arent common. WebFinasteride has been used to shrink prostate and prevent male pattern baldness. Experts believe that the symptoms commonly described as post-finasteride syndrome could be caused by several different factors. Alongside thyroid. Like other medications, finasteride went through several large-scale clinical trials before it finally received approval from the FDA. Although vitamins dont play a role in preventing male pattern baldness, many vitamins are vital for proper hair growth. Inhibitors of 5-steroid reductase are drugs used to treat androgen-dependent conditions including prostate diseases and androgenic alopecia. Although the symptoms of post-finasteride syndrome are alarming, its important to keep in mind that they are incredibly rare, even in long-term finasteride users. Twenty-six men with a history of 5ARI use reporting symptoms consistent with post-finasteride Q2: How many men who take finasteride get PFS? In a small study published in the Journal of Sexual Medicine in 2007, men with benign prostatic hyperplasia were divided into two groups and treated with finasteride. Careers. My biggest issue is low/no libido. In general, side effects from finasteride are rare, with only a small percentage of men affected at the typical finasteride dosage used to treat hair loss. government site. However, it does raise questions about the theory that finasteride has the potential to cause lasting, long-term, severe side effects. In most, but not all, of these men, these sperm parameters will return to normal after quitting the drug. HCG increased my anxiety. Also I dont know how the Sun in Australia would affect you differently maybe the ozone layer there would filter less UV and you gotta take that into account Im sure that has been said somewhere by JK. This site needs JavaScript to work properly. I look and feel so much younger!, When I show my barber my progress, he is always in disbelief. Customers were given free product.. https://www.ncbi.nlm.nih.gov/books/NBK513329/, https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia, https://www.pfsfoundation.org/about-pfs-post-finasteride-syndrome/, https://www.pfsfoundation.org/frequently-asked-questions/, https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020788s028lbl.pdf, https://www.karger.com/Article/Fulltext/497362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401955/, https://pubmed.ncbi.nlm.nih.gov/17655657/, https://pubmed.ncbi.nlm.nih.gov/27662439/, https://medlineplus.gov/genetics/condition/androgenetic-alopecia/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540144/, https://www.ncbi.nlm.nih.gov/books/NBK482378/, https://www.scitcentral.com/article/19/60/Randomized-Comparative-Research-Study-of-Topical-and-Oral-Finasteride-with-Minoxidil-for-Male-Pattern-Androgenetic-Alopecia-in-Indian-Patients, https://www.ijord.com/index.php/ijord/article/view/394, https://rarediseases.info.nih.gov/diseases/12407/adverse-events-of-5-alpha-reductase-inhibitors, many vitamins are vital for proper hair growth. Rather, these Frequently Asked Questions are meant as a starting point for ongoing discussions among patients, doctors and researchers. For example, if a person is aware that a medication can cause headaches, they might become more likely to report experiencing a headache after using the medication. I am doing a High sensativity blood panel soon, would you be able to also look at my blood work to see what could be the problem with everything i am experiencing?Thanks. J Urol. J Endocrinol Invest. - PubMed - NCBI, Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism, Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression, Elevated ESR and hCG levels are strong predictors of impending cancer diagnosis To Extract Knowledge from Matter, Thoughts On 5ar And Post Finasteride Syndrome, Post Finasteride Syndrome And Low Insuline, Post Finasteride Sydrome - Neuropathic Pain, Low-Dose HCG Maintains Intratesticular T In Normal Men With T-Induced Gonadotropin Suppression, DHT And Reversing Androgen-receptor Deficiency, Elevated ESR And HCG Levels Are Strong Predictors Of Impending Cancer Diagnosis, Post Finasteride Sydnrome, And The 5ar1 And 2 Isoenzymes, Post Finasteride/ High Cortisol/ Low Gaba. PFS, which is listed in the National Institutes of Healths Genetic and Rare Diseases Information Center, and in the database of the National Organization for Rare Disorders, describes persistent and serious side effects that continue long after the drug has been discontinued. Before/after images shared by customers who have purchased varying products, including prescription based products. press@forhims.com goes to a third party never send personal, medical, or health information to this address. ***POST FINASTERIDE SYNDROME CAN LAST 3 MONTHS or PERMANENTLY. WebPost-Finasteride Syndrome (PFS) is a term used to describe a complex of symptoms with persistent sexual, neurological, mental, and physical side effects in patients who usually have taken treatment for hair loss, such as Finasteride (marketed under the brand name Propecia or generics) or for enlarged prostate (marketed under the brand name These serious adverse side effects include persistent or irreversible sexual, neurological, physical and mental side effects. Who would have thought trying to enhance the hairline would cause bigger problems! Hair transplant surgery provides permanent results, but it can be costly. thank you, i will try to update in the future. Androsterone both allopregnanolone and androsterone are potent GABA agonists, so might substitute to a degree for each other. I think this is anti-peat. This is especially true once the placebo and nocebo effects are taken into consideration. I havent seen any reports of hcg triggering cell growth. Post-finasteride syndrome is also said to involve mental and neurological symptoms. Keywords: This is a psychological phenomenon in which a persons negative expectations about a specific medication or procedure may cause them to experience a negative symptom. Re: Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians. To build your sollar callus first by getting lots of red/infrared over your skin during low UV hours (early AM and late PM). Ruksiriwanich W, Linsaenkart P, Khantham C, Muangsanguan A, Sringarm K, Jantrawut P, Prom-U-Thai C, Jamjod S, Yamuangmorn S, Arjin C, Rachtanapun P, Jantanasakulwong K, Phimolsiripol Y, Barba FJ, Sommano SR, Chutoprapat R, Boonpisuttinant K. Plants (Basel). Cheers. So lets discuss what the drug, finasteride, does in the first place. Oral testosterone: Hows the best way to take it? Schifano N, Capogrosso P, Boeri L, Fallara G, Chiappini S, Rewhorn M, Cakir OO, Harvey H, Castiglione F, Alnajjar HM, Muneer A, Deho' F, Schifano F, Montorsi F, Salonia A. Int J Impot Res. Etc Etc I started losing hair about 18 yrs old if that helps, Hi I got post finasteride syndrome like side effects from saw palmettherbal blend of dht natural inhibitors from amazon https://www.amazon.com/product-reviews/B004PVLWW0/ref=acr_dp_hist_2?ie=UTF8&filterByStar=two_star&reviewerType=all_reviews#reviews-filter-bar and i did blood work (rosch eclia methodology) but endos cant find anything that could cause all the side effects im dealing with. The study also showed that the longer men are on finasteride, the more likely they are to develop PED. Overall, men who take finasteride for at least 205 days are nearly five times more likely to develop PED than men who take it for less than 205 days. If you have a northern European haplotype with a bad SNP profile and you get no or limited sunlight = no sulfated vitamin D3 = altered estradiol = altered testosterone = no progesterone = dehydration due to poor mitochondrial flux = no sex drive = no sex = no oxytocin = Tensegrity 7 blog. 3 reasons why eating raw bull testicles for boosting testosterone is useless! In theory, the effects could be additive, but it is not known if the added effects would be beneficial or harmful. Q18: Can topical finasteride cause PFS in the same way that oral finasteride does in some men? This would suggest that tapering might be a safer approach. (You must log in or sign up to reply here. I definitely feel ten years younger!, In just as little over two and half months, I can really see the difference in thickness and in color., 4-months strong and my confidence boosted back up to 100% using Hims, future me really does thank me., Im a 34 year old father of two and have been using Hims for over a year now. Prolactin is a bugger when it comes to mood and cognitive function. There are no known scientific reports of PFS patients returning to full health. From 50UI per day. This is a great video Ive shared many times over many HRT forums. The Post-Finasteride Syndrome Foundation 2023, Support Program Connects PFS Patients Worldwide, Genetic and Rare Diseases Information Center, Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors finasteride or dutasteride, Finasteride use in the male infertility population: effects on semen and hormone parameters, Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia. It was described that the prolonged use of 5-steroid reductase inhibitors in patients with alopecia can cause persistent side effects called a post-finasteride syndrome (PFS), that is not just a simple coexistence of events, but rather a definite syndrome with an iatrogenic background. (Needless to say, those professionals dont cover the entire world, which is why were always looking for more. A: Finasteride, even at low doses, may cause reduced sperm counts, sperm concentration and sperm motility that can result in male infertility in some men. Before Over time, it has been considered a safe and well Disclaimer. Do explosive exercises, such as uphill sprints, muscle-ups, jump squats, burpees, etc. What do you think of TRT is PCT to recover from PFS? A: Unfortunately, PFS is still not known or recognized by the large majority of all medical professionals, and many doctors cruelly stigmatize patients. WebPost-finasteride syndrome (PFS) describes persistent sexual, neurological, physical, and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type THC has been shown to increase brain pregnenolone, but this study shows that cannabis users have higher pregnanolone (a 5-metabolite) and lower allopregnanolone (a 5-metabolite) (, Get lots of sunlight, especially in the morning. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A third factor is that a lot of the problems commonly described as symptoms of post-finasteride syndrome are common in middle-aged and older men, particularly men in the age group that is most likely to develop noticeable male pattern baldness. This issue can have a serious impact on a persons risk of experiencing side effects after taking medication, as healthcare providers are required to inform their patients about the potential side effects of medication as part of the treatment process. 2019 Jan 1;99(1):12-17. doi: 10.2340/00015555-3035. WebPost-finasteride syndrome (PFS) describes persistent sexual, neurological, physical and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type II enzyme inhibitor used to treat hair loss (under the brand name Propecia or generics) or enlarged prostate (Proscar or generics). Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. A: Thats a key question in the PFS riddle. and transmitted securely. With that in mind, DHT can take anywhere from4 weeks to 2 years or more to recover(R). We are in contact with many women around the world whove told us that, as a direct result of taking finasteride, they suffer from many of the same symptoms as male PFS patients. Wider recognition of PFS symptoms, its incidence, course, prevention, and treatment possibilities will allow the indications for drug use to be reconsidered and treatment to be more personalized. You do think that these hypothetical damages can be reversed ? If cortisol is low in blood tests, then you can focus on increasing that, but if cortisol is low in saliva tests but high in blood tests, focus on calming the adrenals. Answer: Hormonal optimization while on finesteride there are many options including peptides, and HCG as well as clomid/arimidex. Can you recommend one? Individual results will vary. Among those are more than 6,100 reproductive disorders, 4,100 psychiatric disorders, 3,400 nervous system disorders and 3,100 skin disorders. Its sold under the brand names Propecia and Proscar. I'm a PFS sufferer that has been doing the HCG protocol for only a week now and seeing/feeling amazing benefits already. You can send me an email at menelite101@gmail.com with your labs (and any addition info you might deem relevant) so I can take a look. I am on the transcrotal cream. Thanks for helping people with this truly debilitating syndrome, in my case I was an othewise healthy active 66 year old that was prescribed Dudasteride for an enlarged prostate 3 months ago , after 7 weeks I stopped taking the drug and within several days I came down with a host of symptoms. As a 5-alpha reductase inhibitor, finasteride works by inhibiting the effects of the enzyme thats responsible for converting testosterone into dihydrotestosterone (DHT). Should I stop taking the drug cold turkey, or gradually taper off it? Additionally, the World Health Organizations VigiBase database of adverse reactions to dutasteride paints an epidemiological profile similar to that of finasteride. The .gov means its official. Online ahead of print. Post-finasteride syndrome is characterized Researchers have found low levels of neurosteroids, including allopregnanolone, in the cerebrospinal fluid of post-finasteride syndrome patients. I found some recovery stories with these compounds. But that does not mean you have to live with all the symptoms for that long. After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. Among the men who used the placebo, 5.1 percent also reported experiencing erectile dysfunction. I can definitely have a look for you and see if I find anything that needs optimization. WebRecovered from Post Finasteride Syndrome! Acta Derm Venereol. If youd like to suggest adding one, please email patient manager Philip Roberts at proberts@pfsfoundation.org.). Another related symptom is insomnia or light and disturbed sleep. The Impact of 5-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health. RX MEDS SHIP FREE, IF PRESCRIBED. Do you generally feel overstimulated and suffer from insomnia? Topical TRT will increase DHT even more. Also do you recommend an androsterone supplement, I havent heard of that option so far. Several studies over the past decade, for example, from Dokras,[], Illustration by Marta Pucci. Careers. This is to prevent the many spam account signups which we receive on a daily basis. It may not display this or other websites correctly. Im a newbie here so dont hold me very accountable here.